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gold standard test for tb
A positive IGRA result may not necessarily indicate TB infection, but can also be caused by infection with non-tuberculous mycobacteria. [4][5] However, one of the five sites involved in the CDC study reported less agreement. According to the FDA approved package insert[16] Quantiferon TB Gold In Tube has a consistent specificity of >99% in low risk individuals and a sensitivity as high as 92% in individuals with active disease, depending on setting and extent of disease. This test is recommended for adults who have received BCG (Bacillus Calmette–Guérin) vaccine. Interferon-gamma release assays (IGRAs) are diagnostic tools for latent tuberculosis infection (LTBI). QuantiFERON (QFT) is a registered trademark for the blood draw that tests for latent tuberculosis (TB). Paired with the increased efficiency of testing, the QuantiFERON Gold Plus TB test is the preferred method for TB testing by clinicians today. Centers for Disease Control and Prevention. In the case of serially screened North American healthcare workers, QFT results just above this cutpoint produce false-positive test results that upon repeat testing revert to negative,[10] where tuberculosis screening is often mandated on an annual basis (MMWR June 2010, https://www.cdc.gov/mmwr/preview/mmwrhtml/rr5905a1.htm?s_cid=rr5905a1_e Research at Stanford University and the Veterans Administration has reported the use of a retesting (or borderline) zone below 1.1 IU/ml mitigates 76% of the false-positives, or reversions.,[11][12], Limitations of QFT include the need to draw blood and process it within 16 hours after collection and limited laboratory and clinical experience with the assay.
If you feel this is in error, please contact a site administrator. The two standards for TB testing include a blood draw or skin test. Medical facilities in the US using QFT can be found at http://www.quantiferon.com/irm/content/contact-us1.aspx?RID=342.
Previously, QuantiFERON®-TB Gold was able to be used in any situation in which the Tuberculin Skin Test (TST) was used, without preference. Because IGRAs are not affected by Bacille Calmette-Guérin (BCG) vaccination status, IGRAs are useful for evaluation of LTBI in BCG-vaccinated individuals, particularly in settings where BCG vaccination is administered after infancy or multiple (booster) BCG vaccinations are given. The company was founded in 1994 and is located in Hamilton, NJ, NMS Health
QuantiFERON hasn't been tested on pregnant women, those with HIV, or those who are under age 17. Requires a single patient visit to draw a blood sample. The QuantiFERON-TB Gold test (QFT-G) is a whole-blood test for use as an aid in diagnosing Mycobacterium tuberculosis infection, including latent tuberculosis infection (LTBI) and tuberculosis (TB) disease. QFT is an interferon-gamma (IFN-γ) release assay, commonly known as an IGRA, and is a modern alternative to the tuberculin skin test (TST, PPD or Mantoux).
TST and QFT do not measure the same components of the immunologic response and are not interchangeable. Healthcare industry representatives (HCIRs) are required to undergo a variety of vendor credentialing requirements.
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